Thought I'd start a thread for newer members or musky anglers such as Joe. A place to start and answer the questions new anglers may have.
Joe, in regards to what lures work best you may want to check our annual Catch and Release reports. They are under the Release Reports Tab at the top of the page. There are many ways to catch a muskie here (and anywhere), but the lures listed in our annual release reports are the ones which our members have found to be most productive for the Niagara. The reports go back 25 years.
It is always easier to learn how to approach the Niagara by fishing at least once with an experienced angler. You should at least be able to learn the basics. Eventually you'll decide what type of fishing you enjoy most (casting, jigging, or trolling) and what works best for you. Don't expect to start catching big muskies, or any muskies, right away. There is a learning curve and catching muskies on the Niagara isn't any easier here than the Cassadaga. So if you go out with someone don't be too disappointed if you don't catch a muskie first time out. You'll learn more every time out which will eventually improve your ability to catch. But be aware, muskie fishing will humble the most experienced of us. The key to successful musky fishing is, and always has been, time on the water.
I'm not sure when I will be going out next, but I'll let you know if I need a partner. On he Niagara, you may want to have both a NY and Canadian license, as half the river, and some of its best fishing, is on the Ontario side.